PT-S58

• Target:

  Others|||PPAR

• Related Pathways:

  Metabolism|||Others|||DNA Damage/DNA Repair

• Bioactivity:

  PT-S58 is a PPAR ?/? full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPAR?/?. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.

• Smiles:

  S(NC1=C(OC)C=C(NC(C)(C)C)C=C1)(=O)(=O)C2=C(C(OC)=O)SC=C2

• Molecular Formula:

  C17H22N2O5S2

• Molecular Weight:

  398.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1356497-92-1