DX-8951 Hydroxy-acid

• Description:

  DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models[1].

• UNSPSC:

  12352005

• Target:

  AMPK; Drug Metabolite; Reactive Oxygen Species (ROS)

• Related Pathways:

  Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC1=CC2=NC3=C(CN4C3=CC([C@@](C(O)=O)(O)CC)=C(CO)C4=O)C([C@@H](N)CC5)=C2C5=C1C

• Molecular Formula:

  C24H24FN3O5

• Molecular Weight:

  453.46

• References & Citations:

  [1]Anada T, et al. A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan. J Am Chem Soc. 2025 Jun 25;147 (25) :22161-22175.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [276680-63-8]