DDO-8958

• Description :

  DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity[1].

• CAS Number :

  [3017180-18-3]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Epigenetic Reader Domain

• Related Pathways :

  Apoptosis; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  FC1=C(C=C(C=C1C2=C3NC=NC3=NC=C2)OCC4COC4)C5=C(N(N=C5C)C)C

• Molecular Formula :

  C22H22FN5O2

• Molecular Weight :

  407.44

• References & Citations :

  [1]Chen X, et al. Multi-Water Bridges Enable Design of BET BD1-Selective Inhibitors for Pancreatic Cancer Therapy. J Med Chem. 2025 Mar 13;68 (5) :5719-5735.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported