AR-12463

• Description:

  AR-12463 is a derivative of Trapidil (HY-B1016) . AR-12463 inhibits the conversion of [14C]acetate to cholesterol. AR-12463 significantly reduces the elevation of total cholesterol in rabbit serum and prevents cholesterol incorporation into tissues. AR-12463 can be used to study atherosclerosis.

• UNSPSC:

  12352005

• Target:

  Drug Derivative; Endogenous Metabolite

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Field of Research:

  Cardiovascular Disease

• Smiles:

  OCCN(CCCCC)C1=CC(N2CCCCC2)=NC3=NC=NN31

• Molecular Formula:

  C17H28N6O

• Molecular Weight:

  332.44

• References & Citations:

  [1]Beitz J, et al. Influence of the trapidil derivative AR 12463 on serum and tissue lipids and development of aortic lesions during experimental atherosclerosis in rabbits. Biomed Biochim Acta. 1991;50 (1) :101-7. PMID: 1859385.|[2]Beitz J, et al. Influence of the trapidil derivative AR 12463 on serum and tissue lipids and development of aortic lesions during experimental atherosclerosis in rabbits. Biomed Biochim Acta. 1991;50 (1) :101-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [100557-04-8]