(R) -MK-8353

CAT: 0804-HY-111407BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111407BSize:1 Each
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Description
(R) -MK-8353 ((R) -SCH900353) is the R-enantiomer of MK-8353 (HY-111407) . MK-8353 (SCH900353) is a potent, selective and orally active ERK1 and ERK2 inhibitor with IC50s of 23.0 nM and 8.8 nM, respectively[1].
CAS Number
[2748457-30-7]
Product Name Alternative
(R) -SCH900353
UNSPSC
12352005
Target
ERK
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Purity
96.59
Smiles
O=C([C@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5
Molecular Formula
C37H41N9O3S
Molecular Weight
691.84
References & Citations
[1]Stergios J Moschos, et al. Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight. 2018 Feb 22;3 (4) :e92352.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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A16838-1MK-8353 (SCH900353) 1mg
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