(R,R)-MK 287

(R,R)-MK 287

• CAS Number: 143490-81-7
• UNSPSC Description: (R,R)-MK 287 is a tetrahydrofuran derivative that potently inhibits [3H]C18-PAF binding to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values ??of 6.1, 3.2, and 5.49 nM, respectively. [3H]MK 287 binds to human platelet and PMN membranes with KD values ??of 2.1 and 2.9 nM. When tested on isolated human cells, MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM or ED50=1.5 nM for gel-filtered platelets) and elastase release from PMNs (ED50=4.4 nM). In in vivo studies, MK 287 inhibited PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg).
• Target Antigen: Platelet-activating Factor Receptor (PAFR)
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/r-r-mk-287.html
• Smiles: CCCOC1=C(C=C([C@@H]2O[C@@H](C3=CC(OC)=C(C(OC)=C3)OC)CC2)C=C1OC)S(CCO)(=O)=O
• Molecular Weight: 510.60
• References & Citations: [1]MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported