(E/Z) -3PO

• Description:

  (E/Z) -3PO is a potent PFKFB3 inhibitor. (E/Z) -3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z) -3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphatase

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Purity:

  99.86

• Smiles:

  O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2

• Molecular Formula:

  C13H10N2O

• Molecular Weight:

  210.24

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Emini Veseli B, et al. Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) . FEBS Lett. 2020 Sep;594 (18) :3067-3075.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [13309-08-5]