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(E/Z) -3PO

CAT: 0804-HY-110169-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110169-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -3PO is a potent PFKFB3 inhibitor. (E/Z) -3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z) -3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis[1].
CAS Number
13309-08-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Purity
99.86
Smiles
O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2
Molecular Formula
C13H10N2O
Molecular Weight
210.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Emini Veseli B, et al. Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) . FEBS Lett. 2020 Sep;594 (18) :3067-3075.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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