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GNF-2 (Standard)

CAT: 0804-HY-11007R-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-11007R-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNF-2 (Standard) is the analytical standard of GNF-2. This product is intended for research and analytical applications. GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM [1].
CAS Number
778270-11-4
UNSPSC
12352100
Target
Bcr-Abl; Reference Standards; SARS-CoV
Related Pathways
Anti-infection; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)N
Molecular Formula
C18H13F3N4O2
Molecular Weight
374.32
References & Citations
[1]Adrián FJ, et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2 (2) :95-102.|[2]Kim HJ, et al. The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity. J Leukoc Biol. 2013 Oct 15.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Gnf-2

3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide is a member of pyrimidines.

CAS Number778270-11-4
PubChem CID5311510
IUPAC Name3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
Molecular FormulaC18H13F3N4O2
Molecular Weight374.3
XLogP3.8
Topological Polar Surface Area90.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity497
SMILES
C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F
InChI
InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChIKey
WEVYNIUIFUYDGI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gnf-2
CAS: 778270-11-4
CID: 5311510
Formula: C18H13F3N4O2
MW: 374.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight374.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass374.09906016
Monoisotopic Mass374.09906016
Topological Polar Surface Area90.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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