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GNF-6231 (Standard)

CAT: 0804-HY-100408RSize: 1 EachDry Ice: NoHazardous: No
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Description
GNF-6231 (Standard) is the analytical standard of GNF-6231. This product is intended for research and analytical applications. GNF-6231 is a porcupine (IC50= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction[1][2][3][4].
CAS Number
1243245-18-2
Target
Porcupine; Reference Standards; Wnt
Related Pathways
Others; Stem Cell/Wnt
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(F)=NC=C4)C(C)=C3
Molecular Formula
C24H25FN6O2
Molecular Weight
448.49
References & Citations
[1]Bastakoty, Dikshya et al. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, stem cells and regenerative medicine vol. 2,2 (2016) : 10.16966/2472-6990.111. |[2]Kang, Sheng. Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. Human genetics vol. 139,4 (2020) : 447-459. |[3]Raeisi, Mortaza et al. Porcn as a novel therapeutic target in cancer therapy: A review. Cell biology international vol. 46,12 (2022) : 1979-1991.|[4]Cheng, Dai et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS medicinal chemistry letters vol. 7,7 676-80. 10 May. 2016, |[5]Bastakoty, Dikshya et al. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, stem cells and regenerative medicine vol. 2,2 (2016) : 10.16966/2472-6990.111.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

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BUP11510-01GNF-6231
A16849-25GNF-6231 25mg
A16849-50GNF-6231 50mg
A16849-10GNF-6231 10mg
A16849-5GNF-6231 5mg
A16849-100GNF-6231 100mg
A16849-2GNF-6231 2mg
A16849-10mM-DGNF-6231 10mM * 1mL in DMSO
GTR19274854-01JNJ-6231
A8604-100GNF 5

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