GNF-6231 (Standard)

• Description:

  GNF-6231 (Standard) is the analytical standard of GNF-6231 (HY-100408) . This product is intended for research and analytical applications. GNF-6231 is a porcupine (IC50= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction[1][2][3][4].

• Target:

  Porcupine; Reference Standards; Wnt

• Related Pathways:

  Others; Stem Cell/Wnt

• Field of Research:

  Cancer; Cardiovascular Disease

• Smiles:

  O=C (NC1=NC=C (N2CCN (C (C) =O) CC2) C=C1) CC3=CN=C (C4=CC (F) =NC=C4) C (C) =C3

• Molecular Formula:

  C24H25FN6O2

• Molecular Weight:

  448.49

• References & Citations:

  [1]Bastakoty, Dikshya et al. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, stem cells and regenerative medicine vol. 2,2 (2016) : 10.16966/2472-6990.111. |[2]Kang, Sheng. Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. Human genetics vol. 139,4 (2020) : 447-459. |[3]Raeisi, Mortaza et al. Porcn as a novel therapeutic target in cancer therapy: A review. Cell biology international vol. 46,12 (2022) : 1979-1991.|[4]Cheng, Dai et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS medicinal chemistry letters vol. 7,7 676-80. 10 May. 2016, |[5]Bastakoty, Dikshya et al. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, stem cells and regenerative medicine vol. 2,2 (2016) : 10.16966/2472-6990.111.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1243245-18-2