SB 247083

• Description:

  SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease[1].

• UNSPSC:

  12352005

• Target:

  Endothelin Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Smiles:

  COC (C=C1C (OCC1) =C2) =C2C/C (C (O) =O) =C\C3=C (C4=C (C=C (C=C4) Cl) OCC5=C (C=CC=C5) C (O) =O) N (N=C3) CCCC

• Molecular Formula:

  C34H33ClN2O7

• Molecular Weight:

  617.09

• References & Citations:

  [1]Douglas SA, et al. Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S273-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ETA; ETB

• CAS Number:

  188186-61-0