TIP48/49-IN-1

CAT: 0804-HY-103702Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-103702Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIP48/49-IN-1 (Compound B) is an orally active and specific inhibitor of RUVBL1/2 ATPase, with an IC50 of 59 nM for purified RUVBL1/2. TIP48/49-IN-1 affects DNA replication process, and leads to S-phase arrest. TIP48/49-IN-1 induces apoptosis. TIP48/49-IN-1 inhibits tumor growth and radiosensitizes non-small cell lung cancer cells (NSCLC) [1].
CAS Number
[1807337-58-1]
UNSPSC
12352005
Target
Proton Pump
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
CCOC(C=CC(Cl)=C1)=C1C2=NN=C([C@@H](CCC3)C[C@@H]3C(NC(C(N(C4=CC=CC=C4)N5C)=O)=C5C)=O)O2
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.02
References & Citations
[1]Yenerall P, et al. RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol. 2020 Jan 16;27 (1) :105-121.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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