CDK2-IN-49

• Description :

  CDK2-IN-49 (Compound 5j) is a CDK2 inhibitor with an IC50 of 0.25 μM. CDK2-IN-49 shows potent activity against CDK7 with an IC50 of 0.14 μM. CDK2-IN-49 induces Apoptosis by raising the levels of p53 and Bax protein expression while reducing the amount of Bcl-2. CDK2-IN-49 inhibits cell division. CDK2-IN-49 can be used in the research of cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family; CDK; MDM-2/p53

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  COC1=CC=C(C=C1)/N=N/C2=C3N=CC=C(N3N=C2N)C4=CC=C(C=C4)C

• Molecular Formula :

  C20H18N6O

• Molecular Weight :

  358.40

• References & Citations :

  [1]Elbakry O M, et al. Targeting CDK2 and CDK7: rational design of pyrazolo [1, 5-a] pyrimidine derivatives as potent anticancer agents. New Journal of Chemistry, 2025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported