TIP48/49-IN-1

CAT: 0013-GTR19259534-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19259534-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .

CAS Number

1807337-58-1

Field of Research

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Smiles

O (CC) C1=C (C=2OC (=NN2) [C@@H]3C[C@H] (C (NC=4C (=O) N (N (C) C4C) C5=CC=CC=C5) =O) CCC3) C=C (Cl) C=C1

Molecular Formula

C28H30ClN5O4

Molecular Weight

536.022

Storage Conditions

-20°C

Notes

For research use only.

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TIP48/49-IN-1

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