KRAS-IN-49

• Description:

  KRAS-IN-49 (compound 7b) is a selective and covalent KRAS G13C inhibitor. KRAS-IN-49 covalently binds to Cys13 of KRAS G13C. KRAS-IN-49 can be used for non-small cell lung cancer (NSCLC) research[1].

• UNSPSC:

  12352005

• Target:

  Ras

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  O=C1C(N=CN2[C@@H]3O[C@H](COP(OP(O)(O)=O)(O)=O)[C@@H](OC(N4CCC[C@@H](NC(C=C)=O)C4)=O)[C@H]3OC(N5C[C@@H](CCC5)NC(C=C)=O)=O)=C2N=C(N)N1

• Molecular Formula:

  C28H39N9O15P2

• Molecular Weight:

  803.61

• References & Citations:

  [1]Kirschner T, et al. Targeting KRASG13C with cyclic linker based inhibitors to explore warhead orientation. Sci Rep. 2025 Oct 31;15 (1) :38213.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported