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LY456236 (free base)

CAT: 0804-HY-103566ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103566ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 free base can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 free base has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG. LY456236 free base can be used in epilepsy research[1][3].
CAS Number
338738-57-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; EGFR; mGluR; p38 MAPK
Related Pathways
Apoptosis; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Smiles
COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1
Molecular Formula
C16H15N3O2
Molecular Weight
281.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ravikumar B, et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019 Nov 21;26 (11) :1608-1622.e6.|[2]Kanaya S, et al. Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways. Connect Tissue Res. 2016 Sep;57 (5) :417-26.|[3]Shannon HE, et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology. 2005;49 Suppl 1:188-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; mGluR1

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