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LY456236

CAT: 0804-HY-103566-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103566-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG. LY456236 can be used in epilepsy research[1][2][3].
CAS Number
338736-46-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; EGFR; mGluR; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly456236.html
Purity
99.57
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1.[H]Cl
Molecular Formula
C16H16ClN3O2
Molecular Weight
317.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Ravikumar B, et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019 Nov 21;26 (11) :1608-1622.e6.|[2]Kanaya S, et al. Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways. Connect Tissue Res. 2016 Sep;57 (5) :417-26.|[3]Shannon HE, et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology. 2005;49 Suppl 1:188-95.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; mGluR1

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