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NOD1/2 antagonist-2

CAT: 0804-HY-101927Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101927Size:1 Each
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Description
NOD1/2 antagonist-2 (Compound 26BH) is a dual NOD1/NOD2 antagonist (IC50s: 2.36 μM and 4.16 μM for NOD1 and NOD2, respectively). NOD1/2 antagonist-2 inhibits both NF-κB and MAPK inflammatory signaling, thereby sensitizing Paclitaxel to suppress Lewis lung carcinoma growth[1].
CAS Number
2101736-25-6
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(C1=CC(OC2=CC=CC(N(C)C)=C2)=C(NC(COCC3=CC=CC=C3)=O)C=C1N4)N[C@H](CCC(NCCC)=O)C4=O
Molecular Formula
C32H37N5O6
Molecular Weight
587.67
References & Citations
[1]Wang S, et al. Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. J Med Chem. 2017 Jun 22;60 (12) :5162-5192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOD1; NOD2

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