D3S-001

• Target:

  Ras|||Kras

• Related Pathways:

  MAPK

• Bioactivity:

  D3S-001 is an orally effective KRAS inhibitor. It suppresses the proliferation of the KRASG12C mutants H358 and MIA-PA-CA-2 with IC50 values of 0.6 and 0.44 nM, respectively. D3S-001 exhibits good metabolic stability across multiple species in hepatocytes, liver microsomes, plasma, and whole blood. Additionally, it demonstrates favorable pharmacokinetic properties and antitumor activity in mice.

• Smiles:

  C (OC1=NC (=C2C (=N1) C[C@H] (OC2) C3=C (C (F) (F) F) C (C) =CC (N) =C3F) N4C[C@H] (CC#N) N (C (C (=C) F) =O) CC4) [C@@]56N (C[C@H] (F) C5) CCC6

• Molecular Formula:

  C32H35F6N7O3

• Molecular Weight:

  679.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2914919-85-8