D3S-001

• Target :

  Ras|||Kras

• Related Pathways :

  MAPK

• Bioactivity :

  D3S-001 is an orally effective KRAS inhibitor. It suppresses the proliferation of the KRASG12C mutants H358 and MIA-PA-CA-2 with IC50 values of 0.6 and 0.44 nM, respectively. D3S-001 exhibits good metabolic stability across multiple species in hepatocytes, liver microsomes, plasma, and whole blood. Additionally, it demonstrates favorable pharmacokinetic properties and antitumor activity in mice.

• Smiles :

  C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C)=CC(N)=C3F)N4C[C@H](CC#N)N(C(C(=C)F)=O)CC4)[C@@]56N(C[C@H](F)C5)CCC6

• Molecular Formula :

  C32H35F6N7O3

• Molecular Weight :

  679.66

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2914919-85-8