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FOG-001

CAT: 0931-TP3124-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3124-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3044032-95-0
Target
Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells
Bioactivity
FOG-001 is an efficient inhibitor of β-catenin, with an IC50 value lower than 50 nM. This compound can block the interaction between β-catenin and T-cell factor (TCF) transcription factors, thereby interfering with the related signaling pathways. FOG-001 can effectively inhibit cell proliferation and induce cell cycle arrest. In a mouse xenograft tumor model carrying COLO320DM colon cancer cells (with APC and TP53 mutations), FOG-001 exhibits significant anti-tumor activity. Therefore, FOG-001 is applicable to the research on the mechanism of colon cancer occurrence and treatment.
Molecular Formula
C102H134N18O25S2
Molecular Weight
2076.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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