AK-2292

• Target:

  PROTACs|||STAT

• Related Pathways:

  PROTAC|||JAK/STAT signaling|||Stem Cells

• Bioactivity:

  AK-2292 is a potent and selective STAT5 PROTAC degrader with a DC50 of 0.10 ?M. It induces degradation of STAT5A/B proteins in vitro and in vivo and can cause tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models [1] [2].

• Molecular Formula:

  C52H54F2N7O10PS2

• Molecular Weight:

  1070.13

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C