SMARCA2-IN-8

• Bioactivity:

  SMARCA2-IN-8 (Compound 13) is an orally effective inhibitor targeting the SWI/SNF chromatin remodeling complexes SMARCA2 (also known as Brahma homolog, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1), with IC50 values of 5 nM and 6 nM respectively. This compound inhibits the proliferation of SMARCA2-mutant SKMEL5 cancer cells with an AAC50 of 5 nM and downregulates the expression of the SMARCA2-dependent gene KRT80, showing an AAC50 of 10 nM. Additionally, SMARCA2-IN-8 demonstrates antitumor efficacy and favorable pharmacokinetic properties in mice.

• Smiles:

  O=C(NC=1SN=C(C1)C(F)F)NC2=CC(F)=NC=C2N

• Molecular Formula:

  C10H8F3N5OS

• Molecular Weight:

  303.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2270875-93-7