SMARCA2-IN-8

CAT: 0931-T89051-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T89051-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2270875-93-7
Bioactivity
SMARCA2-IN-8 (Compound 13) is an orally effective inhibitor targeting the SWI/SNF chromatin remodeling complexes SMARCA2 (also known as Brahma homolog, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1), with IC50 values of 5 nM and 6 nM respectively. This compound inhibits the proliferation of SMARCA2-mutant SKMEL5 cancer cells with an AAC50 of 5 nM and downregulates the expression of the SMARCA2-dependent gene KRT80, showing an AAC50 of 10 nM. Additionally, SMARCA2-IN-8 demonstrates antitumor efficacy and favorable pharmacokinetic properties in mice.
Smiles
O=C(NC=1SN=C(C1)C(F)F)NC2=CC(F)=NC=C2N
Molecular Formula
C10H8F3N5OS
Molecular Weight
303.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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