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SUN-1334H free base

CAT: 0931-T87997-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T87997-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
607737-00-8
Target
Dopamine Receptor, Histamine Receptor, Sigma receptor, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Neuroscience
Bioactivity
SUN-1334H free base, an orally active histamine H1 receptor inhibitor, exhibits a K_i of 9.7 nM and an IC 50 of 20.3 nM. Additionally, it effectively prevents histamine-induced contractions in isolated guinea-pig ileum with an IC 50 of 0.198 μM. The compound also blocks histamine-induced bronchoconstriction and skin wheals in guinea pigs and beagle dogs, respectively, and mitigates ovalbumin-induced rhinitis in guinea pigs.
Smiles
C(N1CCN(C/C=C/COCC(O)=O)CC1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Molecular Formula
C23H26F2N2O3
Molecular Weight
416.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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