TRK-IN-28

• Target:

  Trk receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].

• Smiles:

  N(C=1C=2C(NN1)=CC=C(CC3=CC(F)=CC(F)=C3)C2)C=4C5=C(C=C(C=C5)N6CCN(C)CC6)N=CN4

• Molecular Formula:

  C27H25F2N7

• Molecular Weight:

  485.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2991504-43-7