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Progranulin modulator-1

CAT: 0013-GTR19234737-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234737-01Size:50 mg
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Description
Compound 60 (Progranulin Modulator-1) is an orally bioavailable small molecule that enhances progranulin (PGRN) secretion with an EC50 of 83 nM in BV-2 cells. It shows low cytotoxicity and moderate hERG inhibition (IC50 3100 nM), making it a useful research tool for studying PGRN biology in models of neurodegenerative and lysosomal storage disorders.
CAS Number
2641013-11-6
Field of Research
Cell Biology
Smiles
FC1=CC=C ([C@@H]2N (CCC=3C2=CC=CC3) C4=N[C@@H] (CO4) [C@@]5 (F) CNC5) C=C1
Molecular Formula
C21H21F2N3O
Molecular Weight
369.41
Storage Conditions
-20°C
Notes
For research use only.

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