HDAC-IN-56

CAT: 0931-MF-0120690-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0120690-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2814571-89-4
Target
HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
HDAC-IN-56 ((S) -17b), an orally active inhibitor of class I histone deacetylase (HDAC), exhibits inhibitory constants (IC 50) of 56.0 ± 6.0 nM for HDAC1, 90.0 ± 5.9 nM for HDAC2, 422.2 ± 105.1 nM for HDAC3, and greater than 10,000 nM for HDAC4-11. This compound displays robust antitumor activity [1], marked by its ability to significantly elevate intracellular acetylhistone H3 and P21 levels, while also inducing G1 cell cycle arrest and apoptosis effectively.
Smiles
[C@@H](C)(N1N=C(C=CC1=O)C2=CC=C(CN(C)C)C=C2)C3=CC=C(C(NC4=C(N)C=C(F)C=C4)=O)C=C3
Molecular Formula
C28H28FN5O2
Molecular Weight
485.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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