GNF-6

• Target :

  Bcr-Abl

• Related Pathways :

  Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity :

  GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 ?M for c-ABL-T334I, 0.09 ?M for BCR-ABL, and 0.590 ?M for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive 'DFG-out' conformation [1].

• Smiles :

  O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C

• Molecular Formula :

  C22H19F3N6O2

• Molecular Weight :

  456.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  839708-29-1