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GNF-6

CAT: 0931-T86517-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T86517-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
839708-29-1
Target
Bcr-Abl
Related Pathways
Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 ?M for c-ABL-T334I, 0.09 ?M for BCR-ABL, and 0.590 ?M for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive 'DFG-out' conformation [1].
Smiles
O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C
Molecular Formula
C22H19F3N6O2
Molecular Weight
456.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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