GNF-6

• Target:

  Bcr-Abl

• Related Pathways:

  Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity:

  GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 ?M for c-ABL-T334I, 0.09 ?M for BCR-ABL, and 0.590 ?M for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive 'DFG-out' conformation [1].

• Smiles:

  O=C1N (CC=2C (N1C) =NC (N) =NC2) C3=CC (NC (=O) C4=CC (C (F) (F) F) =CC=C4) =CC=C3C

• Molecular Formula:

  C22H19F3N6O2

• Molecular Weight:

  456.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  839708-29-1