Antitumor agent-138

• Target:

  Apoptosis|||Microtubule Associated

• Related Pathways:

  Apoptosis|||Cytoskeletal Signaling

• Bioactivity:

  Antitumor agent-138 (compound 5b), with an IC 50 of 1.87 ?M, inhibits tubulin polymerization at the tubulin colchicine-binding sites. It arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 cells. Additionally, this compound suppresses cell migration and angiogenesis [1].

• Smiles:

  O=C(C1=CC(OC)=C(OC)C(OC)=C1)N2N=C(N)C=C2C=3C=CC(=CC3)C

• Molecular Formula:

  C20H21N3O4

• Molecular Weight:

  367.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2975168-22-8