Antitumor agent-67

• Target:

  Microtubule Associated|||Others

• Related Pathways:

  Cytoskeletal Signaling|||Others

• Bioactivity:

  Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin, thereby killing tumor cells. In HepG2 xenograft models, Antitumor agent-67 significantly inhibits cancer growth with minimal toxicity [1].

• Smiles:

  O=C1[C@@]2 ([C@@H] (C=3C ([C@@H] (OC (OCC4=CC=C (N (C (CC (C) (C) C5=C (C) C (=O) C (C) =C (C) C5=O) =O) C) C=C4) =O) [C@]2 (CO1) [H]) =CC6=C (C3) OCO6) C7=CC (OC) =C (OC) C (OC) =C7) [H]

• Molecular Formula:

  C45H47NO13

• Molecular Weight:

  809.85

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2820146-10-7