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Multi-kinase-IN-6

CAT: 0931-T81740-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T81740-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Pim, EGFR, Chk, Apoptosis, Casein Kinase, ALK, c-Kit, Trk receptor, CDK
Related Pathways
Angiogenesis, Cell Cycle/Checkpoint, Stem Cells, Metabolism, JAK/STAT signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Additionally, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and effectively triggers apoptosis [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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