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Multi-kinase inhibitor 3

CAT: 0931-T200518-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200518-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2648279-76-7
Target
PDGFR, VEGFR, FLT
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.
Smiles
O=C(NC=1ON=C(C1)C(C)(C)C)CC2=CC=C(C=C2)N3C=NC=4C=C(C=CC43)C=5C=NN(C5)C
Molecular Formula
C26H26N6O2
Molecular Weight
454.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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