TRK-IN-23

• Target:

  Apoptosis|||Trk receptor

• Related Pathways:

  Apoptosis|||Tyrosine Kinase/Adaptors

• Bioactivity:

  TRK-IN-23 (compound 24b) is a potent, orally active TRK inhibitor with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].

• Smiles:

  C (=C\1/C=2C (NC1=O) =CC=C (NCC3=C (OC) C=CC (F) =C3) C2) \C4=CN=CN4

• Molecular Formula:

  C20H17FN4O2

• Molecular Weight:

  364.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2924344-29-4