TRK-IN-23

CAT: 0931-T78968-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T78968-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2924344-29-4

Target

Apoptosis, Trk receptor

Related Pathways

Apoptosis, Tyrosine Kinase/Adaptors

Bioactivity

TRK-IN-23 (compound 24b) is a potent, orally active TRK inhibitor with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].

Smiles

C(=C\1/C=2C(NC1=O)=CC=C(NCC3=C(OC)C=CC(F)=C3)C2)\C4=CN=CN4

Molecular Formula

C20H17FN4O2

Molecular Weight

364.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-149965	TRK-IN-23
PA1321-S	Trk-A
338192-01	Trk A
HY-144451	TRK-IN-12
HY-146519	TRK-IN-14
HY-160166	TRK-IN-26
HY-146521	TRK-IN-15
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HY-144423	Trk-IN-10
HY-160165	TRK-IN-25

TRK-IN-23

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