TRK-IN-23

• Target :

  Apoptosis|||Trk receptor

• Related Pathways :

  Apoptosis|||Tyrosine Kinase/Adaptors

• Bioactivity :

  TRK-IN-23 (compound 24b) is a potent, orally active TRK inhibitor with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].

• Smiles :

  C(=C\1/C=2C(NC1=O)=CC=C(NCC3=C(OC)C=CC(F)=C3)C2)\C4=CN=CN4

• Molecular Formula :

  C20H17FN4O2

• Molecular Weight :

  364.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2924344-29-4