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SAH-SOS1A TFA

CAT: 0931-T76059-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T76059-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ras, Kras, Others
Related Pathways
Others, MAPK
Bioactivity
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC 50 =106-175 nM) . SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS [1] .
Molecular Formula
C102H160N27F3O30
Molecular Weight
2301.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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