SAH-SOS1A

• Target:

  Kras|||Ras

• Related Pathways:

  GPCR/G Protein|||MAPK

• Bioactivity:

  KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants) . Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

• Smiles:

  [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@H](C(N[C@]3(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(N)=O)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CC(C)C)=O)(C)CCCC=CCCC3)[H])=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O

• Molecular Formula:

  C100H159N27O28

• Molecular Weight:

  2187.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1652561-87-9