SAH-d4

• Description:

  SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[2].

• Product Name Alternative:

  SAH (S-Adenosylhomocysteine) -d4

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Purity:

  99.0

• Solubility:

  10 mM in DMSO|DMSO : 62.5mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CSC([2H])([2H])C([2H])([2H])[C@H](N)C(O)=O)[C@@H](O)[C@H]3O

• Molecular Formula:

  C14H16D4N6O5S

• Molecular Weight:

  388.44

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234 (3) :603-8.|[3]Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21 (3) :290-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported