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THR-β agonist 6

CAT: 0931-T74785-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74785-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2791290-58-7
Target
Others, Thyroid hormone receptor (THR)
Related Pathways
Others, Endocrinology/Hormones
Bioactivity
THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remarkable liver-to-serum ratio of 93:1 in mouse models, underscoring its efficacy and potential for research in nonalcoholic steatohepatitis (NASH) [1].
Smiles
ClC1=C(N2C3=C(C=C2)N(C(C)C)C(=O)C=C3)C(Cl)=CC(=C1)N4N=C(C#N)C(=O)NC4=O
Molecular Formula
C20H14Cl2N6O3
Molecular Weight
457.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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