HDAC-IN-53

CAT: 0931-T74783-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T74783-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2921948-27-6

Target

Apoptosis, HDAC

Related Pathways

Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair

Bioactivity

HDAC-IN-53 is an orally active, selective inhibitor of HDAC1-3, with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. It exhibits no inhibitory effects on class II HDACs (HDAC4, 5, 6, 7, 9; IC50 >10 μM) . The compound induces caspase-dependent apoptosis and significantly hampers the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice with MC38 colon cancer [1].

Molecular Formula

C23H20ClN7O2

Molecular Weight

461.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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