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PROTAC USP7 Degrader-1

CAT: 0804-HY-175358Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175358Size:1 Each
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Description
PROTAC USP7 Degrader-1 (Compound 40) is a ubiquitin-specific protease 7 (USP7) PROTAC degrader with a DC50 of 25 nM. PROTAC USP7 Degrader-1 can be used for cancers like acute myeloid leukemia (AML) research[1]. Pink: USP7 ligand ; Blue: VHL ligase ligand (HY-112078) ; Black: linker
UNSPSC
12352005
Target
Deubiquitinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCOC2=CC=C(C3=C(C4=NN3C)N=CN(CC5(O)CCN(C(C[C@@H](C)C6=CC=CC=C6)=O)CC5)C4=O)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C7=CC=C(C8=C(N9CCN(CCN(C)C)CC9)N=CS8)C=C7)C
Molecular Formula
C64H86N12O8S
Molecular Weight
1183.51
References & Citations
[1]Wittenburg S, et al. Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability. J Med Chem. 2025 Jul 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7

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