Antitumor agent-61

• Target:

  Apoptosis|||Others

• Related Pathways:

  Apoptosis|||Others

• Bioactivity:

  Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity with IC50 values ranging from 0.92 to 3.23 ?M against six human cancer cell lines: SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63, and specifically induces apoptosis in SK-OV-3 cells via mitochondrial pathways [1].

• Smiles:

  CCOP (=O) (OCC) C (Nc1ccc (CCCC (=O) OC2 (CC) C (=O) OCc3c2cc2-c4nc5ccc (OC (=O) N6CCC (CC6) N6CCCCC6) cc5c (CC) c4Cn2c3=O) cc1) c1ccc (F) cc1

• Molecular Formula:

  C54H63FN5O10P

• Molecular Weight:

  992.08

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2408917-12-2