HDAC-IN-50

CAT: 0931-MF-0146571-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0146571-01Size:25 mg
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CAS Number
2653339-26-3
Target
Others|||FGFR|||Apoptosis|||HDAC
Related Pathways
Chromatin/Epigenetic|||Angiogenesis|||Others|||Tyrosine Kinase/Adaptors|||Apoptosis|||DNA Damage/DNA Repair
Bioactivity
HDAC-IN-50, a potent, orally active inhibitor targeting both FGFR (Fibroblast Growth Factor Receptor) and HDAC (Histone Deacetylase), exhibits IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, HDAC8, respectively. This dual inhibitor induces apoptosis and cell cycle arrest at the G0/G1 phase while decreasing the expression of phosphorylated FGFR1 (pFGFR1), phosphorylated ERK (pERK), and phosphorylated STAT3 (pSTAT3), thus demonstrating anti-tumor activity.
Smiles
N(CCNC(C)C)(C1=CC2=C(C=C1)N=CC(=N2)C3=CN(CCCCCCC(NO)=O)N=C3)C4=CC(OC)=CC(OC)=C4
Molecular Formula
C31H41N7O4
Molecular Weight
575.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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