Antitumor agent-81

• Target:

  Others|||E1/E2/E3 Enzyme|||p62|||Apoptosis

• Related Pathways:

  Apoptosis|||Autophagy|||Others|||Ubiquitination

• Bioactivity:

  Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.

• Smiles:

  O(C)C=1C=C(N2C=C(N=N2)C3=CC4=C(C=C3)N=C(N)N=C4N)C=C(OC)C1OC

• Molecular Formula:

  C19H19N7O3

• Molecular Weight:

  393.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2765180-17-2