BOLD-100 free base

• Target:

  HSP|||Autophagy|||Others

• Related Pathways:

  Cytoskeletal Signaling|||Others|||Metabolism|||Autophagy

• Bioactivity:

  BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.

• Smiles:

  [Cl-][Ru+4] ([Cl-]) ([Cl-]) ([Cl-]) ([N]1=CC=2C=CC=CC2N1) [N]3=CC=4C=CC=CC4N3

• Molecular Formula:

  C14H12Cl4N4Ru

• Molecular Weight:

  479.15

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  783324-98-1