BOLD-100 free base

CAT: 0931-T72543-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T72543-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

783324-98-1

Target

HSP, Autophagy, Others

Related Pathways

Cytoskeletal Signaling, Others, Metabolism, Autophagy

Bioactivity

BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.

Smiles

[Cl-][Ru+4]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3

Molecular Formula

C14H12Cl4N4Ru

Molecular Weight

479.15

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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