BOLD-100 free base

• Target :

  HSP|||Autophagy|||Others

• Related Pathways :

  Cytoskeletal Signaling|||Others|||Metabolism|||Autophagy

• Bioactivity :

  BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.

• Smiles :

  [Cl-][Ru+4]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3

• Molecular Formula :

  C14H12Cl4N4Ru

• Molecular Weight :

  479.15

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  783324-98-1