BOLD-100 free base

CAT: 0931-MF-0146229-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0146229-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
783324-98-1
Target
HSP|||Autophagy|||Others
Related Pathways
Cytoskeletal Signaling|||Others|||Metabolism|||Autophagy
Bioactivity
BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.
Smiles
[Cl-][Ru+4]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3
Molecular Formula
C14H12Cl4N4Ru
Molecular Weight
479.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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M-CEMG2-CSK1-35MiTeGen CryoEM G2 Puck Complete HC35 Starter Kit Contains: 100 Cryo-EM Pucks (M-CEMG2-10) 10 Storage Cane Compatible with HC35 (M-CEMSTC-2) 1 Transport Cane (M-CEMTPC-1) 2 Pair of Puck Grasping Tongs (M-CEMG2-PGT1) 2 Angled Puck Tongs (M-CP-111-030) 2 Puck Dewar and Insert (M-CEM-PD-IS1) 2 Cryo-EM Grid Box Tweezers (TW-EMTEC-553) 2 Screw Driver for Lid Lock (M-CEMG2-LLSD) 1 Barcode Reader (USB) (M-BCR-001) 2 Puck & Cane Tracking Log Book 1 TW35-10 Storage Dewar with Roller Base (TW-TW35-10 & TW-R033-8C00) 1 CX100 Dry Shipper and Original-Style shipping Case (TW-CXS-1) FREE Custom puck Barcoding and Engraving (example: ABC-001 to ABC-010) (M-CEMG2-Barcoding) FREE Custom puck color selection Puck Choose any combination of the following colors: Red, Blue, Purple, Grey, Black, Gold , Green, Violet, Brown, Orange (M-CEMG2-CustomColor)

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