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BOLD-100 (free base)

CAT: 0804-HY-147039-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147039-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR) . BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
CAS Number
783324-98-1
Product Name Alternative
NKP-1339 (free base) ; IT-139 (free base) ; KP-1339 (free base)
UNSPSC
12352300
Target
Autophagy; HSP
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bold-100-free-base.html
Solubility
10 mM in DMSO
Smiles
[Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
Molecular Formula
C14H12Cl4N4Ru
Molecular Weight
479.15
References & Citations
[1]Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14 (2) :238. Published 2022 Jan 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HSP70

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