TRK-IN-32

CAT: 0013-GTR19265101-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19265101-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TRK-IN-32 is a potent TRK inhibitor. It significantly suppresses TRKWT, TRKG595R, and TRKG667C with IC50 values of 0.08 nM, 2.14 nM, and 0.68 nM, respectively. Additionally, TRK-IN-32 exhibits antiproliferative activity against various Ba/F3 cell lines transformed by wild-type, xDFG mutant, solvent front, and gatekeeper mutant TRK fusion proteins. It also induces apoptosis in Ba/F3-TRKAWT and Ba/F3-TRKAG667C cells. TRK-IN-32 is applicable in research on various cancers, including thyroid cancer and secretory breast cancer.

CAS Number

3044124-79-7

Field of Research

Cell Biology, Signal Transduction

Smiles

N ([C@@H] (C) C1=CC=C (F) C=N1) C2=NN3C (=CN=C3C=C2) C4=CC (=NN4) C5CC5

Molecular Formula

C19H18FN7

Molecular Weight

363.39

Storage Conditions

-20°C

Notes

For research use only.

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