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HDAC-IN-91

CAT: 0804-HY-175021Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175021Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-91 is a multiple inhibitor of HDAC (IC50 = 134.22 nM for HDAC1, 66.29 nM for HDAC2), carbonic anhydrase (CA) (Ki = 72.03 nM for CA IX, 50.76 nM for XII), and tubulin polymerization (IC50 = 2.56 μM) . HDAC-IN-91 inhibits PARP1 and increases the Bax/Bcl-2 ratio. HDAC-IN-91 blocks the cell cycle at the G2/M phase and induces apoptosis through a mitochondrial apoptosis activation mechanism. HDAC-IN-91 can exert potent cytotoxic activity through tubulin polymerization inhibition. HDAC-IN-91 can be used in breast, colorectal, cervical and lung cancer research[1].
UNSPSC
12352101
Target
Apoptosis; Bcl-2 Family; Carbonic Anhydrase; Caspase; HDAC; Microtubule/Tubulin; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
BrC1=CC=C(C(/C=C/C2CC=C(OCC(NC3=CC=C(S(N)(=O)=O)C=C3)=O)C=C2)=O)C=C1
Molecular Formula
C23H21BrN2O5S
Molecular Weight
517.39
References & Citations
[1]Mohamed MFA, et al. Synthesis and apoptotic induction of sulfonamide-based chalcone hybrids as first-in-class dual histone deacetylase‑carbonic anhydrase inhibitors with potential anti-tubulin activity. Bioorg Chem. 2025 Jun 20;163:108694.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; CA IX; CA XII; Caspase 7; Caspase 9; HDAC1; HDAC2

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