SKLB-11A

• Target:

  Autophagy|||Sirtuin

• Related Pathways:

  DNA Damage/DNA Repair|||Autophagy|||Chromatin/Epigenetic

• Bioactivity:

  SKLB-11A is a potent allosteric agonist of SIRT3 (sirtuin 3) . It activates signaling pathways associated with autophagy (autophagy), helps prevent mitochondrial dysfunction, and improves cardiac function in models of Doxorubicin-induced cardiotoxicity as well as myocardial ischemia/reperfusion.

• Smiles:

  O=C (OC) C=1C=2N=C3C=CC=CC3=NC2N (C1N) CC4=CC=C (F) C=C4

• Molecular Formula:

  C19H15FN4O2

• Molecular Weight:

  350.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  433953-86-7