SKLB-197

• Target:

  Others|||ATM/ATR

• Related Pathways:

  Others|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

• Bioactivity:

  SKLB-197 is able to act on ATR (IC50: 0.013 ?M), but has little or no activity on the other 402 protein kinases. In vitro and in vivo, SKLB-197 has shown significant antitumour effects against ATM-deficient tumours.

• Smiles:

  C[C@@H]1COCCN1c1nc(nc2ccc(cc12)-c1ccnn1C)-c1cccc2[nH]ccc12

• Molecular Formula:

  C25H24N6O

• Molecular Weight:

  424.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2713577-16-1