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DEG-35

CAT: 0931-T207249-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T207249-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2734910-37-1
Target
Casein Kinase|||IKZF|||Molecular Glues
Related Pathways
PROTAC|||Metabolism|||Stem Cells|||Immunology/Inflammation
Bioactivity
DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1?, with DC50 values of 1.4 nM and 4.4 nM for CK1? and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .
Smiles
O=C(NC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=C5C=C(OC)C=CC5=C4
Molecular Formula
C25H21N3O5
Molecular Weight
443.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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