DEG-35

CAT: 0931-T207249-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207249-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2734910-37-1

Target

Casein Kinase, IKZF, Molecular Glues

Related Pathways

PROTAC, Metabolism, Stem Cells, Immunology/Inflammation

Bioactivity

DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .

Smiles

O=C(NC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=C5C=C(OC)C=CC5=C4

Molecular Formula

C25H21N3O5

Molecular Weight

443.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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DEG-35

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