DEG-35

• Target :

  Casein Kinase|||IKZF|||Molecular Glues

• Related Pathways :

  PROTAC|||Metabolism|||Stem Cells|||Immunology/Inflammation

• Bioactivity :

  DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1?, with DC50 values of 1.4 nM and 4.4 nM for CK1? and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .

• Smiles :

  O=C(NC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=C5C=C(OC)C=CC5=C4

• Molecular Formula :

  C25H21N3O5

• Molecular Weight :

  443.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2734910-37-1