Gal-ARV-771

• Target:

  PROTACs|||Apoptosis|||Epigenetic Reader Domain

• Related Pathways:

  Chromatin/Epigenetic|||Apoptosis|||PROTAC

• Bioactivity:

  Gal-ARV-771 is a PROTAC prodrug, modified with galactose, based on ARV-771. It is activated in senescent cancer cells that express SA-?-Gal, thereby releasing ARV-771. Through the ubiquitin-proteasome pathway, Gal-ARV-771 induces selective degradation of the BRD4 protein in senescent cells and promotes apoptosis (apoptosis) of these cancer cells.

• Molecular Formula:

  C71H84ClN9O19S2

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C