ARV-393

• Target:

  PROTACs|||Bcl-6

• Related Pathways:

  PROTAC|||Immunology/Inflammation

• Purity:

  0.9996

• Bioactivity:

  ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL) .

• Smiles:

  FC1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1C4CCN(CC4)[C@@H]5C[C@@H](OC6CCN(CC6)C=7N=C(NC=8C=C9C(=CC8)N(C(C)C)C(=O)C(OCC(NC)=O)=C9)C(Cl)=CN7)C5

• Molecular Formula:

  C46H53ClFN9O7

• Molecular Weight:

  898.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2851885-95-3