ARV-393

CAT: 0931-MF-0063240-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0063240-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2851885-95-3
Target
PROTACs|||Bcl-6
Related Pathways
PROTAC|||Immunology/Inflammation
Purity
0.9996
Bioactivity
ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL) .
Smiles
FC1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1C4CCN(CC4)[C@@H]5C[C@@H](OC6CCN(CC6)C=7N=C(NC=8C=C9C(=CC8)N(C(C)C)C(=O)C(OCC(NC)=O)=C9)C(Cl)=CN7)C5
Molecular Formula
C46H53ClFN9O7
Molecular Weight
898.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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