OARV-771

• Target :

  PROTACs|||Epigenetic Reader Domain

• Related Pathways :

  PROTAC|||Chromatin/Epigenetic

• Bioactivity :

  OARV-771, a VHL-based BET degrader (PROTAC) featuring enhanced cell permeability, demonstrates DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3, respectively [1].

• Smiles :

  C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

• Molecular Formula :

  C49H59ClN8O8S2

• Molecular Weight :

  987.62

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2683008-37-7